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American Journal of Clinical Nutrition, 115(4), 787-789

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First dose to first week Some users notice effects from the very first dose

While calcium supplementation can help prevent kidney stones, too much calcium can sometimes increase the risk of kidney stones, especially when combined with vitamin D

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Phase II clinical trials for inflammatory bowel disease reported no toxicity or adverse events in treated patients, though detailed safety data from these trials have not been published in peer-reviewed literature