For many patients with obesity or diabetes, the benefits may be significant
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The areas attracting the most focused attention include inflammatory bowel disease, where the preclinical evidence base is deepest
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30 , 31 The administration of NSAIDs is particularly concerning because, although they effectively mitigate pain associated with severe cases of OA, their use is known to be associated with potentially serious dose-dependent gastrointestinal (GI) complications, such as upper GI bleeding