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Volume depletion may cause orthostatic hypotensiona drop in blood pressure upon standingwhich manifests as dizziness or light-headedness, particularly when moving from sitting or lying to standing positions

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Replacing the phenyl ring with a heterocyclic moiety was also well tolerated and resulted in potent hits (cluster-2)

Such biomarkers are gaining traction as noninvasive tools to complement endoscopy in IBD management

Further studies are required to assess the safety of these products

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