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Acknowledgements We thank the study subjects for participating in this clinical trial

Vitamin B12 deficiency is a well-recognized cause of neurological symptoms such as paresthesia, cognitive slowing, and abnormal sensory perceptions, even in the absence of subacute combined degeneration (SCD) of the spinal cord

Activated Parkin ubiquitinates outer mitochondrial membrane proteins including Mfn1, Mfn2, Miro1, and VDAC1 (Tanaka et al., 2010), followed by PINK1-mediated phosphorylation of these ubiquitinated substrates to amplify polyubiquitin chain signaling (Harper et al., 2018)

Hygiene is paramount to prevent contamination

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Sadly, many deaths occurred before safety measures were introduced