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Moreover, cancer stem cells (CSCs) tend to rely on OXPHOS rather than glycolysis as their primary energy source, a metabolic trait that confers enhanced therapeutic tolerance and tumor-initiating capacity [27]
For example, a phase Ib trial using PD-1 antibody toripalimab and vascular endothelial growth factor receptors (VEGFR) inhibitor axitinib showed a dramatical improvement in ORR and PFS to 61% and 9.1 months separately (178, 179), although the safety and efficacy of this combination strategy needs to be further validated
GLP-1 is an endogenous insulinotropic hormone secreted from L cells of the small intestine, that participates in the homeostatic regulation of insulin and glucose by activating GLP-1R [21, 22]
515.237.5237 x417 Amber Hallengren joined Respite Connection as a Service Supervisor in 2025, bringing more than 20 years of dedicated experience in the human services field
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