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Oxidative stress is significant because this renders the central nervous system exquisitely sensitive to free radical attack

Dig Dis Sci 65:32973304

The data suggests that certain populations are at elevated risk due to pharmacogenetic, metabolic, or disease-specific vulnerabilities

91 Moreover, the role of intermittent fasting in improving cardiovascular diseases also relies on ketone generation and the enhancement of risk factors such as obesity and lipid imbalances

AIFM2, which we renamed ferroptosis suppressor protein 1 (FSP1) and which was initially described as a pro-apoptotic gene, confers protection against ferroptosis elicited by GPX4 deletion