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Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]

However, these findings prompted further research to clarify the nature of this association

It works by inhibiting appetite and increasing satiety, thereby reducing energy intake

doi: 10.1155/2019/5080843 32 YangJHuSBianYYaoJWangDLiuXet al

Its not a matter of willpower or desire

Why should we reconsider how these drugs are prescribed