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A Canadian population-based cohort study by Leon et al showed that, in Ontario, stopping RAASi therapy increased the risks of both overall death and need for dialysis [5]

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determined that it is the proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons in the ARC that are the direct targets of liraglutide-induced weight loss, whereas the NTS, area postrema, PVN, and vagus nerve are not involved

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