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Such upregulation was not observed in schizophrenia [56], suggesting that the upregulation of apoptotic gene expression is unlikely to be related to mania but may subserve the dominant phase of bipolar depression

Neurology 82:13621369 El-Mezayen NS, Abd el Moneim RA, El-Rewini SH (2022) Vitamin B12 as a cholinergic system modulator and blood brain barrier integrity restorer in Alzheimers disease