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The right dose depends on the indication, the patients weight and health history, and the prescribing providers clinical judgment

For example, naproxen and ketoprofen, which bind within the hydrophobic pocket close to Trp-213, result in greater fluorescence quenching than ibuprofen and diazepam which bind away from Trp-213 [74,75,76]

TB-500 component: 5mg twice weekly during intensive phase, maintaining this elevated dose for 2-4 weeks before transitioning to standard maintenance

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