This disparity is ascribed to variations in screening methodologies (eg, prevalent prostate-specific antigen [PSA] testing in affluent nations resulting in overdiagnosis), lifestyle determinants (eg, Western diets abundant in red meat and fat, obesity), aging demographics, and genetic predisposition (eg, elevated risk in populations of African descent)
doi:10.4021/jem157w
Epigenetic Mechanisms of Peptidergic Regulation of Gene Expression during aging of Human Cells
Comparison of plasma histamine and tryptase
These results led to an improved understanding of WS and identification of a drug combination to help patients, which is currently in an ongoing phase 2 clinical trial (223, 224)
Mix 10 g (1.5 tablespoons) with 200 ml water, once a day