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Research indicates that plasma levels of the mots c peptide in middle-aged and older individuals are 11% and 21% lower, respectively, than those found in youth

People who take medications regularly that decrease stomach acid production can also become deficient in vitamin B12 for this reason, whether they consume enough from their diets or not

PMID 13374343

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For this reason, the Food and Nutrition Board of the National Academy of Medicine advises that all adults limit their intake of folic acid (supplements and fortification) to 1,000 g (1 mg) daily