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Interestingly, we noted that expression levels of serine/glycine synthesis enzymes are elevated by at least 4-fold in 80% of all T-cell leukaemias, whereas the RPL10 R98S mutation is only present in 8% of the samples, suggesting that other factors may be driving serine/glycine synthesis addiction in this type of cancer

113,114 Substrates recruited by Yos9 and Hrd3 are delivered to a complex containing Hrd1 and Der1, where the substrate associates with a groove in Hrd3 and a Yos9 lectin domain (on its luminal side) while its loop is inserted into the ER membrane

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This selective action makes Ipamorelin useful for studies that require growth hormone stimulation without broader hormonal effects

A strict vegetarian diet may lead to deficiency of LC since red meat is the richest source of lysine

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