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increase cerebral blood flow (Kramar et al., 1997)

Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4

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Intestinal Permeability and Hypertension: The Chicken and Egg Question A key question that remains is if hypertension leads to increased internal permeability, or if intestinal permeability, caused by other factors such as low fibre intake, gut dysbiosis, medication or comorbidities such as obesity, activates inflammatory processes that contribute to the development of hypertension