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Vascular and angiogenic endpoints include: VEGF expression CD34 markers factor VIII markers vascular density endothelial response eNOS signalling NO pathway markers blood flow related tissue response This pathway helps explain why BPC-157 appears in so many different tissue models

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Acknowledgements We acknowledge the staff of the Department of Neurosurgery who participated in the care of the patient and Professor Jacob Scheinider who prepared the histologic pictures of the case