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5.3 The "Tregs-Microglia-Neuron/NPCs" axis and GLP-1R/cAMP/PKA/IL-10 mediated immunosuppressive and neuroprotective effects of GLP-1RAs in ischemic stroke In summary, in the pathological state of ischemic stroke, T cells preferentially migrated to the lesion boundary, and significantly increased after ischemia, peaking in the following weeks and persisting for several months (71)