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In several Phase III clinical trials (such as the SURPASS series), Tirzepatide was signicantly superior to Semaglutide and insulin in reducing glycated hemoglobin (HbA1c) and body weight

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Janine A, Kim MM, Sandra E, Karin W, Ingrid S, Julian GM, et al

Membranes were blocked with 5% BSA in TBS0.01% Tween 20 and probed with specific antibodies against PGC-1 (ab176328) and GCL-c (ab53179) purchased from Abcam

The statistical analysis was carried out by GraphPad Prism 8 (San Diego, CA, USA) using an unpaired t-test or two-way analysis of variance (ANOVA) with Bonferronis post-test

Retatrutides 24.2% weight loss compares to the 25-30% typically seen with gastric sleeve surgery, offering similar results without surgical risks or anatomical changes