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Our clinical mantra is cautious curiosity: we are curious enough to try new tools, but cautious enough to prioritize safety, transparency, and measurable goals

Medicines and surgery Overweight and obesity management (NG246)

The CEL files (data files used by Affymetrix software, used by the Broad Institute) were processed with MAS5 (Microarray Analysis Suite 5 software, Affymetrix, Santa Clara, CA, USA) and background correction

5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

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