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Inclusion Criteria Exclusion Criteria Timeline for a Trial Participant Screening Participants are screened for eligibility to participate in the trial Treatment Participants receive retatrutide or placebo subcutaneously once weekly Follow-up Participants are monitored for safety and effectiveness after treatment What Are the Treatments Tested in This Trial

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Hence, in patients with CKD and eGFR 20 mL/min/1.73 m 2 , we favor the use of SGLT2is to slow kidney disease progression [6, 27]

From a tolerance perspective, the multi-receptor mechanism offers theoretical advantages