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Until these results are available, GLP-1 receptor agonists with established cardiovascular benefits (liraglutide, semaglutide, dulaglutide) are preferred by ADA guidelines for patients with established atherosclerotic cardiovascular disease

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However, DHA itself induced ERS in glioma cells by activating PERK-ATF4-HSPA5, increasing the expression and activity of GPX4, thereby neutralizing DHA-induced lipid peroxidation and protecting glioma cells from ferroptosis

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