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Consistent with this, increasing central leptin desensitizes its physiological responses over time (36) rendering lean rodents more prone to diet-induced obesity (37)

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Support metabolic adaptation The side effects of MOTS-c largely reflect metabolic stress as your body adapts

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Despite its advantages, the medication has drawn attention due to potential side effects and complications, which have become the focal point of various legal proceedings concerning its safety and labeling practices

5 Future directions and clinical significance Overall, ANGPTL4 demonstrates dual roles, serving as both a DKD biomarker and a therapeutic target (Srivastava et al., 2024