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These data support an effect of IL-13 to decrease total and reduced GSH through high 15LO1, PEBP1, and GPX4 activity, which is partially compensated by (a) increased expression/activity of SLC7A11 to enhance new intracellular GSH production and (b) increased export of GSSG

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Patients were randomized to receive dulaglutide (1.5 mg weekly) or placebo, with a median follow-up of 5.4 years

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For individuals with obesity or metabolic challenges, semaglutide may provide a more controlled and effective solution