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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Barnett C., Costill D.L., Vukovich M.D., Cole K.J., Goodpaster B.H., Trappe S.W., Fink W.J

Expert Opinion on Biological Therapy (2012) 11

Van Gaal, L.F

Berberine as a therapy for type 2 diabetes and its complications: from mechanism of action to clinical studies

Phase 2 data demonstrated: Up to 86% relative reduction in liver fat content Over 85% of participants on higher doses achieved resolution of hepatic steatosis More than 90% of participants with obesity and NAFLD achieved liver fat normalisation at top dose These findings suggest glucagon receptor agonism may play a pivotal role in lipid oxidation and hepatic fat mobilisation an area of intense scientific interest in UK metabolic research