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For example, in a postmenopausal woman with low estrogen - if the 2OH/4OH ratio is low (indicating a preference for the more damaging 4-OH pathway), however, the 4-OH value is at the low end of the postmenopausal range, then the low ratio may not be as concerning

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10.1371/journal.pone.0018138 10 DahlgrenK

It might begin to degrade, losing its potency and leaving your reconstituted peptide vulnerable