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In the causal process, the product of the a path quantifies the effect of independent variables (l-carnitine, betaine or DMG) on the mediator (TMAO), and the product of the b path quantifies the effect of the mediator (TMAO) on the dependent variable (NAFLD), controlling for independent variables (Reference Sobel19)

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J Neurochem 108(5):12205 Prez-De La Cruz V, Carrillo-Mora P, Santamara A (2012) Quinolinic acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms

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PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

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