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This can increase discomfort, cause more prominent lumps or welts, slow absorption, and sometimes trigger injection site reactions

PD clinical trials The neuroprotective effects of GLP-1RAs, particularly exenatide, seem to be more promising in PD

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However, the complexity of human brain injury and the limitations of animal models in predicting human neurological outcomes require extensive clinical validation before considering these applications

Chronic systemic inflammation is also associated with elevated lipolysis in white adipose tissue and lipogenesis in nonadipose tissues, causing ectopic fat deposition in nonadipose tissues and imbalance in free fatty acid homeostasis and increased risk of IR [63]