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For patients with moderate constipation, osmotic laxatives such as macrogol are particularly effective in softening stools and increasing bowel movement frequency

doi: 10.1016/j.smrv.2023.101836, 13

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The IGF-1 axis is also mechanistically entangled with cell proliferation in ways that intersect with cancer biology, which is one reason the muscle-specific splice approach was originally pursued as a way to gain local anabolic signaling without the oncogenic side effects observed for IGF-1. [6] None of this constitutes a safety assessment for humans

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