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Antibody specific for phospho-GCN2 (Thr 899) was from Abcam (Cambridge, UK)

Las absorbancias fueron medidas en espectrofotmetro marca Beckman y las concentraciones se determinaron en funcin de una relacin lineal elaborada con curva de estndares

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In the comprehensive preclinical studies, MDR-001 has demonstrated excellent functional potency and selectivity, with favorable ADME properties and oral bioavailability, as well as desirable pharmacokinetics and tolerability