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Notably, when combined with immunosuppressive drugs, Clostridium s immunomodulatory effects may enhance immune activity and compromise drug efficacy, requiring close monitoring of immune function and timely dosage adjustments

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Also, the M1 phenotype has a role in amplifying necroptosis of endothelial cells and disruption of BBB following ischemic stroke (Jiang et al

Most published work is in rodent models

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