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GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis (PLoS ONE)

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The efficacy and safety of tirzepatide were next evaluated in a 26-week, double-blind, placebo-controlled trial in subjects with T2D inadequately controlled with diet and exercise alone or treated with stable metformin therapy [85]

When semaglutide was tested in obesity trials, participants lost an average of about 15% of their body weightfar exceeding the results seen with earlier anti-obesity drugs

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