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J Am Coll Cardiol (2004) 43:13437.10.1016/j.jacc.2003.10.060 166 GallettiFCupiniLMCorbelliICalabresiPSarchielliP

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Dysbiosis-induced circadian disruptions have been implicated in sleep disturbances, mood disorders, and metabolic dysfunctions [165, 166]

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Furthermore, microcrystalline urate deposition activates the NLRP3 inflammasome in renal and vascular tissues, exacerbating kidney disease and cardiovascular complications through IL-1-mediated inflammation (Wang Q