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Cells 12 , 2544 (2023)

doi:10.1002/jnr.23335

Peyronies Disease can be treated through various nonsurgical methods like injections, oral medicines, and medical therapies, alongside surgical procedures like grafting, plication, and device implantation

It acts as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis, influencing the release of key hormones such as luteinizing hormone and supporting natural testosterone and estrogen signaling

MAPKs, including extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), and p38 MAPKs, regulate various cellular activities such as growth, differentiation, and apoptosis

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