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10.3390/nu12010015 Nutrients

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Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology [5]

doi: 10.1016/j.molcel.2010.06.029

The significance of this weak binding to IGFBPs is that the compound can exert more pharmacological action in animal subjects since IGFBPs decrease the pharmacological activity of hormones that are strongly bound to it

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