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In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

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Definitions and inclusion/exclusion criteria Concerning ES: ES was defined as stress during early-life, from conception up to up to 18 years of age (human studies) or weaning (preclinical studies)