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Dehydroascorbate (DHA) and ascorbate free radical (AFR), as an intermediate, the ascorbate free radical (AFR), that are reversible, one-electron oxidations are generated from ascorbate (Figure 4)

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These agents activate AMP-activated protein kinase signaling, leading to suppression of mammalian target of rapamycin complex 1 activity and reduced expression of pro-inflammatory cytokines and adhesion molecules [29]

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