doi: 10.1038/s41580-021-00392-4 87 ItakuraEKishi-ItakuraCMizushimaN
In the docking between amlodipine and AGE pathway proteins, promising results were also obtained, and a systematic literature review confirmed the antioxidant effect of amlodipine
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The pharmacological and genetic antagonism of PKC protected against APAP-mediated liver injury by inhibiting JNK activation, while JNK1 and JNK2 silencing in vivo decreased APAP-mediated PKC translocation to mitochondria, unraveling a feed-forward mechanism involved in APAP hepatotoxicity
[115], in a meta-analysis with network pharmacologya discipline which attempts to understand drug actions and interactions with multiple targetsincluding ten studies (both RCTs and non-RCTs) involving 576 patients with MASLD, highlighted an association between metformin and reduced triglyceride (TG) levels (mean decrease (MD) = 0.17, 95% CI = 0.26 to 0.08), total cholesterol (MD = 0.29, 95% CI = 0.47 to 0.10), and insulin resistance (MD = 0.42, 95% CI = 0.82 to 0.02)
