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Ssentongo P, Ssentongo AE, Voleti N, Groff D, Sun A, Ba DM, et al
At the protein level, juglone has been shown to specifically inhibit a few purified enzymes by covalently modifying their active site cysteine residues
& Struthers, A
West EE, Merle NS, Kamiski MM, Palacios G, Kumar D, Wang L, et al
In order to elucidate in vivo mechanism of aldehyde-mediated tissue injury in ALDH2*2 carriers, here we investigate the pathology of Aldh2*2 knock-in (KI) mice with AA-induced acute exposure to acrolein, focusing on relationship between rapid systemic storm of reactive aldehydes and hepatocellular injury characterized by accumulation of aldehyde adducts
Preserving NADH entry into the respiratory chain with NDI1 prevented these manifestations despite similar weight gain, indicating that mitochondrial electron entry controls metabolic health independently of body weight
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