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NeuroReport 7:18331836 Raps SP, Lai JC, Hertz L, Cooper AJ (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

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While it is better absorbed than berberine, standard oral ALA still has a relatively low bioavailability of around 30% and a very short half-life due to rapid hepatic degradation