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Oxidative stress is caused by an imbalance between the production of highly reactive molecules, such as ROS and hydrogen peroxide, and enzymatic and non-enzymatic cellular antioxidant mechanisms (6)

Similarly, a recent cross-sectional study in healthy nurses found that NS workers had significantly lower plasma melatonin levels compared to DS workers, alongside trends toward altered leptin, ghrelin, and metabolic parameters, supporting the role of circadian disruption in predisposing to metabolic syndrome, which is a risk factor for BC development 175

Hepatocyte Growth Factor (HGF) (294HGN100) was from R&D Systems, Minneapolis, MN

The ethanol-induced CYP2E1 expression in the cell activates Nrf2 and increases GSH synthesis in hepatocytes [17]

Pyridoxine for nausea and vomiting of pregnancy: A randomized, double-blind, placebo-controlled trial