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Interestingly, NAFLD patients exhibited increased DNL even during fasting 52 , indicating the lack of metabolic flexibility in these patients as opposed to the robust suppression of DNL during fasting observed in healthy individuals 44,53

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[2] [11] The American Diabetes Association recommends specific GLP-1 receptor agonists as preferred agents for patients with type 2 diabetes who have established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk