Residues forming this surface cleft and cavity come from both the N-terminal domain (Tyr10, Phe11, Phe13 Arg16, Met38) and from the C-terminal domain (Glu103, Asp104, Tyr106, Arg107, Tyr110, Phe113, Arg114)
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This method (systematic review) has evolved over the last 20 to30 years and is widely and increasingly used to underpin clinical practice guidelines, Dr
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