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Notably, emodin has progressed to ex vivo human validation using RA patient-derived primary synoviocytes, increasing its relevance to human pathology

2025;131:e35662

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[DOI] [PubMed] [Google Scholar] 124.Guo CH

M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., Jugold, M., Guillemin, G

Additionally, recent research has demonstrated that in tumor cells, lactate and ATP can be catalyzed by alanyl-tRNA synthetase, specifically AARS1, to form lactate-AMP, which subsequently combines with the lysine residues of proteins, resulting in lactylation [23]