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It is estimated that the burden will double over the next two decades (Checkoway et al

Furthermore, under normal physiological conditions following birth, term newborns readily acquire sufficient L-carnitine through enteral feeds

2 The British Society for Haematology recommends intramuscular vitamin B 12 for severe deficiency and malabsorption syndromes, whereas oral replacement may be considered for patients with asymptomatic, mild disease with no absorption or compliance concerns

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