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We found that PD-1 + non-exhausted-like T cells (PD-1 + Lag-3 ) displayed higher levels of GSH than exhausted-like (PD-1 + Lag-3 + ) and other control cell subsets (Supplemental Figure 1O), while stem-like progenitors (Ly108 + CD69 + ) displayed the highest levels of GSH among all cell subsets in transferred infiltrating CD8 + T cells (Supplemental Figure 1P)

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Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule

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The enzyme involved in glutamine synthesis, GS, is also involved in tumor biology

(PubMed) de Rooij BM, Boogaard PJ, Rijksen DA, Commandeur JN, Vermeulen NP