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Commonly reported side effects include gastrointestinal discomfort

Much of the research over the last couple of decades has focused on thrombosis and reducing the risk of excessive blood clotting, as this is substantially associated with vascular stiffness, reduced blood flow, and an increased risk of embolism, cardiovascular disease, and heart failure

2022 Jul;352:88-95

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According to clinical trial data and post-marketing surveillance, these effects are generally dose-dependent (more common with higher doses) and tend to diminish over time as the body adapts to the medication

Dietary triglycerides (approximately 100 grams per day) are hydrolyzed to free fatty acids and monoacylglycerol by intestinal lipases and emulsified with bile acids, cholesterol, plant sterols, and fat-soluble vitamins to form micelles