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Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48

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4C), NSBSO treated 4T1 cells exhibited shrunken mitochondria with decreased mitochondria cristae, morphological changes from ellipsoid to spheroid, accompanied with damage of mitochondria (Fig

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