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For adults with a BMI of 40 kg/m2 or higher or those with a BMI of 35 kg/m2 or higher with obstructive sleep apnea or prediabetes, Apovian recommends strongly considering bariatric surgery as a first-line therapy due to very low complication rates and robust and durable weight loss

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Bozdagi O, Tavassoli T, Buxbaum JD (2013 Apr 27) Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

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