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PlexusDx's Precision Peptide Genetic Test doesn't predict rebound with certainty, but it identifies genetic variants (GLP1R rs6923761, FTO rs9939609, MC4R rs17782313, GIPR rs1800437) that influence appetite sensitivity and metabolic rate

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This transcriptional memory is driven by epigenetic changes, including histone deacetylation (mediated by histone deacetylases, HDACs) and repressive histone methylation (H3K27 trimethylation) at inflammatory gene loci (Maleszewska et al., 2021)

Damjanovic, J., Miao, J., Huang, H

As well as dietary changes which can be helpful

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