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Carnosine, which has been demonstrated in previous studies to exert direct antioxidant effects, is primarily synthesized in muscle tissue

The authors note that these genes are not only associated with key functions such as cognition, sleep and memory that are impaired in ME/CFS but also with those symptoms (mood disorders and anxiety) in which ME/CFS symptomology often overlaps with psychiatric disorders raising the possibility of shared neurological underpinnings

But well also see mood swings, appetite swings, sweats, night sweats, difficulty with temperature regulation

No, most clients find the pain very tolerable

Additional NMR data are included in the Source Data file

Diving into TB500: What Is It Exactly