Some patients notice uneven lightening, particularly in areas exposed to sun
Both substances can have significant effects on the bodys hormonal balance, and long-term use without medical supervision can lead to severe health complications
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Guidelines produced by the UK and the FDA suggest that a weight loss of between 5% and 10% should be considered clinically meaningful 33 - 35 (refer to Appendix 4 for a detailed review) and a 5% reduction from baseline was a co-primary outcome in 3 of the STEP trials